منابع مشابه
Efficacy of Prolonged Treatment With Pegylated Interferon (Peg-IFN) and Ribavirin in Thalassemic Patients With Hepatitis C Who Relapsed After Previous Peg-IFN-Based Therapy
BACKGROUND Most thalassemic patients with chronic hepatitis C virus (HCV) infection do not respond to therapy with pegylated interferon (Peg-IFN) plus ribavirin (RBV) due to hepatic siderosis and RBV dose reduction caused by RBV-induced anemia. OBJECTIVES In the present study, we recruited HCV genotype 1-infected thalassemic patients who had relapsed after a 48-week treatment with Peg-IFN plu...
متن کاملOptimizing treatment for HCV genotype 4: PEG-IFN alfa 2a vs. PEG-IFN alfa 2b; the debate continues.
Hepatitis C virus (HCV) remains one of the leading causes of morbidity and mortality worldwide. Combined therapy with pegylated interferon (PEG-IFN) and ribavirin is the current standard of care treatment for HCV genotype 4. Two types of PEG-IFN are commercially available. The limited number of trials that were conducted for HCV genotype 4 and the few head to head comparisons make it impossible...
متن کاملefficacy of prolonged treatment with pegylated interferon (peg-ifn) and ribavirin in thalassemic patients with hepatitis c who relapsed after previous peg-ifn-based therapy
background most thalassemic patients with chronic hepatitis c virus (hcv) infection do not respond to therapy with pegylated interferon (peg-ifn) plus ribavirin (rbv) due to hepatic siderosis and rbv dose reduction caused by rbv-induced anemia. objectives in the present study, we recruited hcv genotype 1-infected thalassemic patients who had relapsed after a 48-week treatment with peg-ifn plus ...
متن کاملMumps virus Enders strain is sensitive to interferon (IFN) despite encoding a functional IFN antagonist
Although the Enders strain of mumps virus (MuV) encodes a functional V protein that acts as an interferon (IFN) antagonist, in multi-cycle growth assays MuV Enders grew poorly in naïve ('IFN-competent' Hep2) cells but grew to high titres in 'IFN-compromised' Hep2 cells. Even so, the growth rate of MuV Enders was significantly slower in 'IFN-compromised' Hep2 cells when compared with its replica...
متن کاملInterferon Gamma Unresponsiveness Due to Down-Regulation of IFN-γR Expression in Experimental Cutaneous Leishmaniasis
It is now well documented that interferon gamma (IFN-γ) is the indispensable cytokine for inducing protective immunity against experimental and human cutaneous leishmaniaisis. The importance of IFN-γ receptor (IFN-γR) has also been studied. In the present study, we made attempts to find out whether L. major infection is able to alter the expression of IFN-γR in vivo. In addition, we studied the...
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ژورنال
عنوان ژورنال: Journal of Drug Targeting
سال: 2017
ISSN: 1061-186X,1029-2330
DOI: 10.1080/1061186x.2017.1363214